hero

Leverage our network to build your career.

Senior Research Associate I/II - In Vivo

MR

Monte Rosa Therapeutics

Boston, MA, USA
Posted on Thursday, June 27, 2024

Senior Research Associate I/II – In Vivo

Job Locations US-MA-Boston
ID
2024-1113
Category
Biology
Position Type
Regular Full-Time

Overview

Monte Rosa Therapeutics is searching for a Sr Research Associate I or II in Immunology/Oncology to provide expertise in developing innovative molecular glue degraders, aiming to deliver a new generation of treatments to patients. This individual will design and execute pivotal proof-of-concept studies in pre-clinical models of inflammation, immunology, and oncology, and assist in the cross-functional development of our research strategy. The role involves interacting with team members to design and execute in vivo/ex vivo pharmacology studies aimed at defining the activity and mechanism of action of compounds. Significant cross-functional collaboration with a talented and dedicated group of scientists including chemists, cell biologists, immunologists, will ensure a diverse exposure to the drug discovery process. This person will work primarily in our Animal Care Facility, with an opportunity to expand their scope at the lab bench.

Responsibilities

  • Perform basic and intermediate veterinary technical tasks in mice independently, including the following:
    • Administration of selected agents by PO, IP, IV, IM, SC routes.
    • Blood sampling techniques via multiple routes, including submandibular bleed.
    • Tumor implantation on flank, followed by tumor volume measurements.
    • Preparation of compound formulation for in vivo
  • Optimize and perform studies to define target biology in mouse models of inflammation and immunity for in vivo, in vitro and ex vivo
  • Maintain accurate laboratory records/notebooks, procedures, and data summaries.
  • Generate high-quality data reports and provide suggestions for future work to management and project teams.

Qualifications

  • BS/MS in Biology, Pharmacology, Animal Science, or related field with minimum 4 years relevant experience in an industry setting.
  • AALAS certification at the ALAT level is preferred. Uncertified candidates must obtain ALAT certification within 12 – 18 months or demonstrate substantial progress toward certification. LVT qualification is a plus.
  • Prior experience necessary in handling compounds for formulation preparation, with a strong emphasis on safety and proficiency in performing necessary calculations.
  • Strong experience in animal handling is required, including compound administration by multiple routes, harvesting tissue and blood samples, and performing necropsy techniques. Experience with surgical techniques is a plus.
  • Experience in culturing mammalian cell lines is advantageous.
  • Experience with pharmacodynamics assays of mouse tissue, including Western Blotting, ELISA/Mesoscale and flow cytometry is a plus.

Options

Sorry the Share function is not working properly at this moment. Please refresh the page and try again later.
Share on your newsfeed
Application FAQs

Software Powered by iCIMS
www.icims.com